Rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions. Review 2019-02-17

Rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions Rating: 9,7/10 995 reviews

Review

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

Add to that a bunch of mislabeled cell lines and mishandled ingredients, and what seems like a potential cure becomes an unreliable mess. Drug trials are incredibly expensive in terms of the time and money spent by the government and researchers—as well as the pain, dashed hopes, and even deaths of the patients enrolled. In the end this topic like so many others leads me to conclude: regulation, regulation, regulations!!! Or how many times scientists cause their own downfall by not doing blind testing. People know, on one plane, that a lot of these ideas are really in play. Some of the information did not surprise me. People may be dismissive of climate science, but they accept a lot of other scientific ideas. Other vital reagents, like antibodies, similarly go untested.

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Out with the Bad Science

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

Studies must be replicated before they are relied on to direct future research. Harris's book reminds us that the problem with science is that scientists are--unfortunately--human, and just as humans have managed to make messes of religion and government and whatever else we get our hands on, science is not immune. As award-winning science journalist Richard Harris reveals in Rigor Mortis, this is not simply the result of trial and error, which is an essential part of the scientific process. Science progresses by testing ideas indirectly, throwing out the ones that seem wrong, and building on those best supported by the facts at hand…. Other scientists had often overlooked those pitfalls. What else has been done? We basically try to create the cancer in mice before we cure it. The more exuberant apologists for science will tell us that unlike religious prophecy, science gains from failed predictions.

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Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions eBook: Richard Harris: vs-forum.jp: Kindle Store

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

Some of the information in the book did not surprise me. In the 21st century, it is exponentially harder to find new drugs than it was in the 20th, and increasingly, young researchers around the world are feeling the grind. Don't they know the golden rule? It's pathetic really, and Harris does a fabulous job of bringing it all to light. The amount of lab space for biomedical research increased by 50 percent, and universities created a flood of new jobs. The shocking part was that we said it out loud.

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NPR Choice page

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

Cells act differently when grown in one brand of Petri dish as opposed to another, and they are responsive to the temperature and humidity levels in a room. And I think that that's — I think that of all the sort of easy to describe solutions, I think that one would go a long way. A hypothesis is considered scientific only if there is the possibility to disprove the hypothesis. Complex new technologies have opened up millions of new possibilities for discovering agents of disease or possible treatments, while creating countless new opportunities for failure in the process. A copy of this book was provided by the publisher in exchange for an honest review. However, the Institutional or governmental watchdog departments are being gutted by, for example, Republican Party government budgets in America not in the book, this comment is on me, acquired from reading other sources. Will it be called Rigor Vita or — Harris: Ooh.

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A journalist shines a harsh spotlight on biomedicine’s reproducibility crisis

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

This book made me question a lot of choices people have made within my field. The most frightening question is, in the long run, can these problems actually be fixed? Suffice it to sa This is a difficult book to review as many terms that would be used in the review are not easily translated into an elemental language for those who have little knowledge of cell categories and other extremely specific particles and culture lines used in research. In reality, very little breakthrough science has occurred since the 1980's. His six-foot-three frame and barrel chest gave him a solid presence. That in turn can dramatically change how hardy they are.

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NPR Choice page

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

Biomedical science is falling sway to the law of diminishing returns. I am less encouraged by evidence of improved training and movement away from the impact factor. Of the thirty big studies done before the law took effect, 57 percent showed that the drug or supplement being tested was beneficial. In fact, there's a group that has been trying to pull together a list of all of these contaminated cell lines. In 2015 a discussion was opened as to how things might be improved. And of those 53, ultimately, he was only able to reproduce 6, which is, what? Rigor Mortis explores these urgent issues through vivid anecdotes, personal stories, and interviews with the nation's top biomedical researchers, some of whom are now struggling to set things right.

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RIGOR MORTIS by Richard Harris

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

The scientists calling out problems worry about their own careers; universities worry about their reputations and potential lawsuits brought by the accused. Not just by intent but by the volume of dependable factors that are exact. He cites published in Nature in 2012 by C. And, sometimes, experiments are simply designed poorly. It's a madhouse that encourages positive results at the cost of good science.

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Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions eBook: Richard Harris: vs-forum.jp: Kindle Store

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

But I think we on this subcommittee, we need to know why so many published results in peer-reviewed publications are unable to be successfully reproduced. Rigor Mortis is rife with examples of things that go awry in medical studies, how they happen, and how they can be avoided and fixed. That said, it is popular science, so it probably is oversimplified in various horrible ways. What next All is not doom and gloom, though; Harris offers solutions. But the clinical relevance and applicability of these studies is still very variable. Because the mice react chemically very different to male lab assistants than they do to female lab assistants. This is one of those times that I hate capitalism--if our researchers had the ability to really focus on what they were doing instead of feeling pressured to have positive results, we'd probably already have cured infertility and cancer and Alzheimer's by now.

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How sloppy science creates worthless cures and wastes billions

rigor mortis how sloppy science creates worthless cures crushes hope and wastes billions

But, we can start talking about the deepest issue, which is — I think that there's something amiss with the culture right now in science, in biomedical research in particular. And everything I did for those 10 years was actually a mistake. Harris reports that drug trials do, in fact, often fail. There are basically three types of experiments proposed by scientists. Unfortunately, the problems frequently aren't identified until long after the paper has Disturbing, but interesting and easy to understand. The system remains far out of balance. It is a professional and genteel read.

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